Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 3/20 | 0.43 |
| ▸ | FNTB | P49356 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296470 | 0.89 | MEN1 (0.42) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5550240 | 0.85 | MEN1 (0.49) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL1538310 | 0.84 | MEN1 (0.59) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5023770 | 0.82 | KDM4E (0.52) | MEN1KMT2APGRHPGDMAPK1 | |
| SCHEMBL5657749 | 0.81 | MEN1 (0.52) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5657976 | 0.80 | MEN1 (0.51) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL6009577 | 0.78 | MEN1 (0.49) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL5550230 | 0.78 | FNTA (0.47) | KMT2AFNTAFNTBSLC9A1 | |
| SCHEMBL5656275 | 0.77 | MEN1 (0.48) | MEN1KMT2ARXFP1FNTAFNTB | |
| SCHEMBL6171109 | 0.75 | SLC9A1 (0.40) | SLC9A1SMN1; SMN2HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322650-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024686-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |