Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL28875352 | 0.91 | ALDH1A1 (0.61) | ALDH1A1TSHRTDP1TRPA1PTGS2 | |
| Styrene SCHEMBL28359473 | 0.88 | TSHR (0.47) | ALDH1A1TSHRTDP1LMNAPTGS2 | |
| Styrene SCHEMBL9467161 | 0.86 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1LMNAPTGS2 | |
| Styrene SCHEMBL27968255 | 0.85 | ALDH1A1 (0.44) | ALDH1A1TSHRTDP1TRPA1LMNA | |
| Styrene SCHEMBL27891207 | 0.84 | ALDH1A1 (0.64) | ALDH1A1TSHRTDP1LMNATP53 | |
| Styrene SCHEMBL3206232 | 0.84 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1LMNATP53 | |
| Styrene SCHEMBL27201704 | 0.84 | ALDH1A1 (0.78) | ALDH1A1TSHRTDP1LMNAPTGS2 | |
| Styrene SCHEMBL28134369 | 0.84 | ALDH1A1 (0.78) | ALDH1A1TSHRTDP1LMNAPTGS2 | |
| Styrene SCHEMBL27565237 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1LMNAPTGS2 | |
| Styrene SCHEMBL11688868 | 0.82 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023184494-A1 | POSITIVE ELECTRODE ACTIVE MATERIAL AND PREPARATION METHOD THEREFOR, POSITIVE ELECTRODE PLATE COMPRISING SAME, SECONDARY BATTERY AND ELECTRIC DEVICE | 宁德时代新能源科技股份有限公司 | 2023-10-05 | — | — | WO | claimed |
| EP-0287603-B1 | SUNSCREEN COMPOSITIONS AND COMPOUNDS FOR USE THEREIN | ICI AUSTRALIA OPERATIONS (AU) | 1993-12-22 | — | — | EP | claimed |
| EP-0287603-A4 | SUNSCREEN COMPOSITIONS AND COMPOUNDS FOR USE THEREIN | — | 1991-12-27 | — | — | EP | claimed |
| US-5000946-A | Sunscreen compositions and compounds for use therein | ICI AUSTRALIA OPERATIONS PROPRIETARY LIMITED, 1 NICHOLSON STREET, MELBOURNE, VICTORIA 3001, AUSTRALIA, A COMPANY OF AUSTRALIA | 1991-03-19 | — | — | US | claimed |
| EP-0287603-A1 | SUNSCREEN COMPOSITIONS AND COMPOUNDS FOR USE THEREIN. | ICI AUSTRALIA OPERATIONS (AU) | 1988-10-26 | — | — | EP | claimed |
| WO-1988002251-A1 | SUNSCREEN COMPOSITIONS AND COMPOUNDS FOR USE THEREIN | ICI AUSTRALIA OPERATIONS PROPRIETARY LIMITED (AU) | 1988-04-07 | — | — | WO | claimed |
| CN-114891466-A | Preparation method of single-component high-performance modified chloroprene water-based emulsion spray adhesive | 广东泰强化工实业有限公司 | 2022-08-12 | — | — | CN | disclosed |
| WO-2020223275-A1 | SANITIZING COMPOSITIONS | LONZA LLC (US) | 2020-11-05 | — | — | WO | disclosed |
| CN-109415249-A | Sacrificial layer for electrochromic device manufacture | 唯景公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-106280196-A | A kind of heat resistant unsaturated polyester resin | 安徽省新力复合材料有限公司 | 2017-01-04 | — | — | CN | disclosed |
| US-8232324-B2 | Electrolyte membrane-forming curable resin composition, and preparation of electrolyte membrane and electrolyte membrane/electrode assembly | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20060194890-A1 | Electrolyte membrane-forming curable resin composition, and preparation of electrolyte membrane and electrolyte membrane/electrode assembly | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2006-08-31 | — | — | US | disclosed |