Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6010317 | 0.88 | ADORA2A (0.43) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL24901912 | 0.75 | ADORA2A (0.54) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6009997 | 0.74 | ADORA2A (0.44) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5095982 | 0.74 | ADORA2A (0.47) | ADORA2A | |
| SCHEMBL5410921 | 0.73 | ADORA2A (0.51) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5096036 | 0.70 | — | — | |
| SCHEMBL23447728 | 0.70 | ADORA3 (0.64) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6010026 | 0.70 | ADORA2A (0.45) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6009718 | 0.68 | — | — | |
| SCHEMBL5109101 | 0.67 | ADORA3 (0.45) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618108-A2 | TRIAZOLO[1,5-A]PYRIMIDINES AND PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS A2A ADENOSINE RECEPTOR ANTAGONISTS | Biogen Idec MA Inc. (US) | 2006-01-25 | — | — | EP | claimed |
| WO-2004092171-A2 | TRIAZOLO[1,5-A]PYRIMIDINES AND PYRAZOLO[1,5-A]PYRIMIDINES USEFUL AS A2A ADENOSIN E RECEPTOR ANTAGONISTS | BIOGEN IDEC MA INC. (US) | 2004-10-28 | — | — | WO | claimed |