Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1,2,3,4-Tetrahydroisoquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 3/20 | 0.79 |
| ▸ | CD44 | P16070 | 1/20 | 0.79 |
| ▸ | MAOB | P27338 | 1/20 | 0.79 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | PRCP | P42785 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL4779021 | 0.94 | PNMT (0.76) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL4007316 | 0.92 | PNMT (0.73) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL6647088 | 0.92 | PNMT (0.73) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL29360217 | 0.89 | PNMT (1.00) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL19085 | 0.89 | PNMT (1.00) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28236302 | 0.89 | PNMT (1.00) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL8788628 | 0.89 | PNMT (0.68) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL6304293 | 0.89 | PNMT (0.68) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL11441365 | 0.89 | PNMT (0.68) | PNMTCD44MAOBHTR2CPRCP | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL4430790 | 0.89 | PNMT (0.68) | PNMTCD44MAOBHTR2CPRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812185-B1 | USE OF ANGIOGENESIS SUPPRESSORS FOR INHIBITING HAIR GROWTH | GILLETTE CO (US) | 2002-07-03 | — | — | EP | claimed |
| EP-0861236-B2 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED ALPHA-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-08-16 | — | — | EP | disclosed |
| EP-1185869-B1 | LIGAND-ANCHOR CONJUGATES FOR PRODUCING A BIOSENSOR LAYER | GRAFFINITY PHARMACEUTICALS AG (DE) | 2006-07-26 | — | — | EP | disclosed |
| EP-0773955-B1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AG (DE) | 2003-04-16 | — | — | EP | disclosed |
| EP-1185869-A2 | LIGAND-ANCHOR CONJUGATES FOR PRODUCING A BIOSENSOR LAYER | Graffinity Pharmaceutical Design GmbH (DE) | 2002-03-13 | — | — | EP | disclosed |
| EP-0861236-B1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED ALPHA-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AG (DE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000073796-A2 | LIGAND-ANCHOR CONJUGATES FOR PRODUCING A BIOSENSOR LAYER | GRAFFINITY PHARMACEUTICAL DESIGN GMBH (DE) | 2000-12-07 | — | — | WO | disclosed |
| EP-0896580-A1 | SPECIFIC IMMUNOPHILIN LIGANDS AS ANTIASTHMATICS AND IMMUNOSUPPRESSANTS | ASTA Medica Aktiengesellschaft (DE) | 1999-02-17 | — | — | EP | disclosed |
| EP-0861236-A1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED ALPHA-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997041148-A1 | SPECIFIC IMMUNOPHILIN LIGANDS AS ANTIASTHMATICS AND IMMUNOSUPPRESSANTS | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1997-11-06 | — | — | WO | disclosed |
| WO-1997018194-A1 | CYCLIC AND HETEROCYCLIC N-SUBSTITUTED α-IMINOHYDROXAMIC AND CARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-22 | — | — | WO | disclosed |
| EP-0773955-A1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-21 | — | — | EP | disclosed |
| WO-1995035309-A1 | NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE | BASF AKTIENGESELLSCHAFT (DE) | 1995-12-28 | — | — | WO | disclosed |
| EP-0578163-A1 | Process for the preparation of D,L or D,L-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-01-12 | — | — | EP | disclosed |