SCHEMBL6011016

SCHEMBL6011016

O=C(O)Nc1ccc(NC(=O)c2nccs2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 9/20 0.58
CASP3 P42574 3/20 0.49
SENP8 Q96LD8 3/20 0.49
SENP7 Q9BQF6 3/20 0.49
SENP6 Q9GZR1 3/20 0.49
AURKA O14965 1/20 0.46
PIM1 P11309 1/20 0.46
CDK2 P24941 1/20 0.46
GSK3B P49841 1/20 0.46
ALDH1A1 P00352 1/20 0.46
AGER Q15109 1/20 0.46
CYP2C19 P33261 2/20 0.45
ADORA2A P29274 2/20 0.45
CYP3A4 P08684 1/20 0.45
PKM P14618 1/20 0.44
MEN1 O00255 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
MAPT P10636 1/20 0.44
CYP2C9 P11712 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL470920 0.89 GRM4 (0.60) GRM4CASP3SENP8SENP7SENP6
SCHEMBL168594 0.88 GRM4 (0.63) GRM4CASP3SENP8SENP7SENP6
SCHEMBL1091625 0.85 GRM4 (0.56) GRM4CASP3SENP8SENP7SENP6
SCHEMBL6655345 0.85 KMT2A (0.61) GRM4CASP3SENP8SENP7SENP6
SCHEMBL12181073 0.85 ALDH1A1 (0.58) GRM4CASP3SENP8SENP7SENP6
SCHEMBL5164235 0.84 GRM4 (0.59) GRM4CASP3SENP8SENP7SENP6
SCHEMBL7361894 0.82 GRM4 (0.53) GRM4CASP3SENP8SENP7SENP6
SCHEMBL7125558 0.81 GRM4 (0.53) GRM4CASP3SENP8SENP7SENP6
SCHEMBL12465944 0.79 MAPT (0.49) GRM4CASP3SENP8SENP7SENP6
SCHEMBL1091450 0.78 NAMPT (0.52) GRM4CASP3SENP8SENP7SENP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1673357-A2 HETEROARYLAMINOSULFONYLPHENYL DERIVATIVES FOR USE AS SODIUM OR CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2006-06-28 EP disclosed
WO-2005013914-A2 HETEROARYLAMINOSULFONYLPHENYL DERIVATIVES FOR USE AS SODIUM OR CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN VERTEX PHARMACEUTICALS INCORPORATED (US) 2005-02-17 WO disclosed