Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 8/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | AGER | Q15109 | 1/20 | 0.48 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6011016 | 0.89 | GRM4 (0.58) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL6655345 | 0.84 | KMT2A (0.61) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1091625 | 0.84 | GRM4 (0.56) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL168594 | 0.83 | GRM4 (0.63) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL12181073 | 0.83 | ALDH1A1 (0.58) | GRM4SMN1; SMN2KDM4EALDH1A1CASP3 | |
| SCHEMBL6660832 | 0.82 | GRM4 (0.60) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7361894 | 0.81 | GRM4 (0.53) | GRM4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL7125558 | 0.80 | GRM4 (0.53) | GRM4RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL1091450 | 0.80 | NAMPT (0.52) | GRM4CASP3SENP8SENP7SENP6 | |
| SCHEMBL5164235 | 0.79 | GRM4 (0.59) | GRM4NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012033069-A1 | PROSTAGLANDIN D SYNTHASE INHIBITORY PIPERIDINE COMPOUNDS | 大鵬薬品工業株式会社 (JP) | 2012-03-15 | — | — | WO | disclosed |
| EP-1442041-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003040147-A1 | AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE__________________________________________________________________________________________________________________________ | PHARMACIA & UPJOHN COMPANY (US) | 2003-05-15 | — | — | WO | disclosed |