Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2936497 | 0.86 | KDM4E (0.45) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL2930621 | 0.76 | KDM4E (0.47) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6517141 | 0.71 | KDM4E (0.46) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6012080 | 0.69 | KDM4E (0.42) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL28383326 | 0.68 | NR1H4 (0.50) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6012061 | 0.68 | NR1H4 (0.56) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6011764 | 0.68 | TGFBR1 (0.39) | — | |
| SCHEMBL6011922 | 0.68 | NR1H4 (0.53) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL6012052 | 0.66 | KDM4E (0.39) | NR1H4KDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL13341943 | 0.65 | ALDH1A1 (0.47) | KDM4EALDH1A1RAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682549-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | Sepracor Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044818-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | SEPRACOR, INC. (US) | 2005-05-19 | — | — | WO | disclosed |