Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216568 | 0.86 | KDM4E (0.52) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL5253722 | 0.86 | KDM4E (0.52) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL6216380 | 0.84 | KDM4E (0.50) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL5250625 | 0.83 | GABRA1 (0.52) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL6216161 | 0.83 | GABRA1 (0.52) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL7998726 | 0.80 | TP53 (0.56) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL6216979 | 0.79 | NR1H4 (0.54) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL436359 | 0.78 | GABRA1 (0.58) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL2931603 | 0.78 | NPC1 (0.46) | KDM4EHPGDGABRA1GABRB2HSD17B10 | |
| SCHEMBL8094715 | 0.77 | KDM4E (0.50) | KDM4EHPGDGABRA1GABRB2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682549-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | Sepracor Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044818-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | SEPRACOR, INC. (US) | 2005-05-19 | — | — | WO | disclosed |