Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.73 |
| ▸ | POLB | P06746 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | IP6K1 | Q92551 | 10/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.61 |
| ▸ | IP6K2 | Q9UHH9 | 9/20 | 0.51 |
| ▸ | IP6K3 | Q96PC2 | 8/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4934034 | 0.84 | ALDH1A1 (1.00) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL31265142 | 0.84 | KDM4E (0.73) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL25352733 | 0.84 | KDM4E (0.73) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL30967420 | 0.82 | IP6K1 (1.00) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL25990902 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL1757999 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL29080634 | 0.78 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL6199027 | 0.76 | KDM4E (1.00) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL13208416 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBSMN1; SMN2MAPT | |
| SCHEMBL25991593 | 0.75 | IP6K1 (0.81) | ALDH1A1KDM4EPOLBSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067531-B2 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-27 | — | — | US | disclosed |
| US-20030199547-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives | JANSSEN-CILAG S.A. (FR) | 2003-10-23 | — | — | US | disclosed |
| EP-1322644-A1 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024687-A1 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199547-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives | FNTA, FNTB, RCE1 | ALDH1A1 645/4885KDM4E 2224/4885POLB 4392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.