Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935650 | 0.85 | GABRA1 (0.61) | GABRA1GABRB2KDM4EHPGDHSD17B10 | |
| SCHEMBL6011922 | 0.83 | NR1H4 (0.53) | NR1H4GABRA1GABRB2KDM4EHPGD | |
| SCHEMBL6012061 | 0.81 | NR1H4 (0.56) | NR1H4GABRA1GABRB2KDM4EHPGD | |
| SCHEMBL6012116 | 0.78 | GAA (0.45) | NR1H4GABRA1GABRB2KDM4EHPGD | |
| SCHEMBL5409725 | 0.75 | NR1H4 (0.47) | NR1H4GABRA1GABRB2KDM4EHPGD | |
| SCHEMBL6012071 | 0.75 | NR1H4 (0.45) | NR1H4GABRA1GABRB2KDM4EHPGD | |
| SCHEMBL8286547 | 0.73 | GABRB2 (0.63) | NR1H4GABRA1GABRB2KDM4EHPGD | |
| SCHEMBL4254698 | 0.71 | GABRA1 (0.60) | GABRA1GABRB2KDM4EHPGDHSD17B10 | |
| SCHEMBL2935921 | 0.71 | GABRA1 (0.53) | GABRA1GABRB2KDM4EHPGDHSD17B10 | |
| SCHEMBL8267987 | 0.70 | GABRA1 (0.53) | NR1H4GABRA1GABRB2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682549-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | Sepracor Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044818-A2 | IMIDAZO[1,2-A]PYRIDINE ANXIOLYTICS | SEPRACOR, INC. (US) | 2005-05-19 | — | — | WO | disclosed |