Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL420358 | 0.74 | IDO1 (0.40) | PDPK1KDRPDGFRBKITFLT3 | |
| SCHEMBL423508 | 0.72 | KDR (0.36) | PDPK1KDRPDGFRBKITFLT3 | |
| SCHEMBL421542 | 0.69 | GLRA3 (0.46) | KDRKIT | |
| SCHEMBL6012201 | 0.67 | PDPK1 (0.32) | PDPK1KDRKITFLT3 | |
| SCHEMBL423869 | 0.66 | ALDH1A1 (0.47) | — | |
| SCHEMBL420454 | 0.64 | HRH4 (0.41) | PDPK1 | |
| SCHEMBL419576 | 0.62 | PDPK1 (0.49) | PDPK1KDRPDGFRBKITFLT3 | |
| SCHEMBL424795 | 0.60 | PDPK1 (0.49) | PDPK1JAK2KDRKITFLT3 | |
| SCHEMBL425657 | 0.60 | PDPK1 (0.49) | PDPK1JAK2KDRKITFLT3 | |
| SCHEMBL422600 | 0.57 | ALDH1A1 (0.40) | PDPK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638941-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |