Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 11/20 | 0.50 |
| ▸ | CA2 | P00918 | 11/20 | 0.50 |
| ▸ | CA4 | P22748 | 11/20 | 0.50 |
| ▸ | CA6 | P23280 | 11/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15270863 | 0.84 | CDK1 (0.60) | CA1CA2CA4CA6MEN1 | |
| SCHEMBL7219608 | 0.81 | GSK3B (0.54) | CDK1CCNB2CCNB1GSK3BCCNB3 | |
| SCHEMBL30394416 | 0.73 | KMT2A (0.40) | CA1CA2CA4CA6KMT2A | |
| SCHEMBL12274879 | 0.70 | CDK2 (0.48) | CA1CA2CA4CA6MEN1 | |
| SCHEMBL6012204 | 0.69 | CDK1 (0.76) | CA1CA2CA4CA6CDK1 | |
| SCHEMBL2298597 | 0.67 | CA1 (1.00) | CA1CA2CA4CA6MEN1 | |
| SCHEMBL29370925 | 0.67 | CA1 (1.00) | CA1CA2CA4CA6MEN1 | |
| SCHEMBL25235469 | 0.66 | HTR2A (0.47) | CA1CA2CA4CA6MEN1 | |
| SCHEMBL12126575 | 0.66 | CA1 (0.71) | CA1CA2CA4CA6MEN1 | |
| SCHEMBL30063877 | 0.66 | CA1 (0.71) | CA1CA2CA4CA6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042867-A2 | MODULATORS OF MULTIPLE KINASES | EMILIEM INC. (US) | 2008-04-10 | — | — | WO | disclosed |
| EP-1086105-B1 | FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS | US GOV HEALTH & HUMAN SERV (US) | 2006-03-01 | — | — | EP | disclosed |