Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 12/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.54 |
| ▸ | CDK1 | P06493 | 12/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 11/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 11/20 | 0.54 |
| ▸ | KIF11 | P52732 | 3/20 | 0.49 |
| ▸ | MDH2 | P40926 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6012236 | 0.81 | CA1 (0.50) | GSK3BCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL15270863 | 0.81 | CDK1 (0.60) | GSK3BCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL5688281 | 0.70 | GSK3B (1.00) | GSK3BCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL4130017 | 0.67 | KIF11 (1.00) | KIF11CHUK | |
| SCHEMBL27354120 | 0.66 | KIF11 (0.56) | GSK3BCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL29507666 | 0.65 | KIF11 (0.81) | KIF11CHUK | |
| SCHEMBL412032 | 0.65 | KIF11 (0.81) | KIF11CHUK | |
| SCHEMBL28372461 | 0.64 | GPR3 (0.49) | KIF11 | |
| SCHEMBL16085082 | 0.64 | GSK3B (0.85) | GSK3BCDK5CDK5R1CDK1CCNB2 | |
| SCHEMBL2289172 | 0.64 | KIF11 (0.61) | GSK3BCDK5CDK5R1CDK1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610684-B2 | Antiproliferative agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-08-26 | — | — | US | claimed |