Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 3/20 | 0.44 |
| ▸ | PTPN13 | Q12923 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPRA | P18433 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | PTPRE | P23469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186093 | 0.90 | MAPT (0.51) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL2255249 | 0.89 | ALDH1A1 (0.58) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL16651569 | 0.89 | KMT2A (0.53) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL29087668 | 0.84 | HSD17B10 (0.67) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL22650326 | 0.84 | HTT (0.50) | ALDH1A1HSD17B10MAPTKDM4EHPGD | |
| SCHEMBL30587103 | 0.83 | ALDH1A1 (0.51) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL28329030 | 0.83 | ALDH1A1 (0.58) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL25556511 | 0.83 | ALDH1A1 (0.51) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL28327811 | 0.83 | HPGD (0.58) | ALDH1A1POLBHSD17B10MAPTKDM4E | |
| SCHEMBL6046819 | 0.83 | KMT2A (0.53) | ALDH1A1POLBHSD17B10MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086105-B1 | FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS | US GOV HEALTH & HUMAN SERV (US) | 2006-03-01 | — | — | EP | disclosed |
| US-6610684-B2 | Antiproliferative agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-08-26 | — | — | US | disclosed |
| US-20020042412-A1 | Fused azepinone cyclin dependent kinase inhibitors | HEALTH AND HUMAN SERVICES, DEPARTMENT OF, GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE, THE | 2002-04-11 | — | — | US | disclosed |
| EP-1086105-A1 | FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999065910-A9 | FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS | US HEALTH (US) | 2000-03-16 | — | — | WO | disclosed |
| WO-1999065910-A1 | FUSED AZEPINONE CYCLIN DEPENDENT KINASE INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042412-A1 | Fused azepinone cyclin dependent kinase inhibitors | CCNI, CCNK, CDKN1A | ALDH1A1 275/4885POLB 1764/4885HSD17B10 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.