Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6012414 | 0.85 | SIGMAR1 (0.44) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL6012549 | 0.80 | LTA4H (0.47) | TSHRLTA4HHRH3ALDH1A1MEN1 | |
| SCHEMBL6012315 | 0.78 | MEN1 (0.37) | TSHRHRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL6012435 | 0.77 | SIGMAR1 (0.53) | TSHRALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL19603222 | 0.76 | KDM4E (0.45) | TSHRALDH1A1TP53MEN1KMT2A | |
| SCHEMBL14872735 | 0.74 | TSHR (0.72) | TSHRLTA4HHRH3RAB9ANPC1 | |
| SCHEMBL17696112 | 0.74 | TSHR (0.67) | TSHRHRH3RAB9ANPC1ALDH1A1 | |
| SCHEMBL1077100 | 0.71 | SIGMAR1 (0.51) | TSHRALDH1A1MEN1KMT2ACYP2D6 | |
| SCHEMBL21538553 | 0.70 | MEN1 (0.50) | TSHRALDH1A1MEN1KMT2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL2235571 | 0.70 | TSHR (0.56) | TSHRLTA4HHRH3RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119091-B2 | Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-10-10 | — | — | US | disclosed |