Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.52 |
| ▸ | CCR5 | P51681 | 15/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6611988 | 0.93 | POLB (0.53) | POLBCXCR3CCR5KMT2A | |
| SCHEMBL6012293 | 0.92 | POLB (0.51) | POLBCXCR3CCR5KMT2A | |
| SCHEMBL6012214 | 0.92 | POLB (0.51) | POLBCXCR3CCR5KMT2A | |
| SCHEMBL6012653 | 0.91 | CCR5 (0.52) | POLBCXCR3CCR5KMT2A | |
| SCHEMBL6012247 | 0.91 | CCR5 (0.52) | POLBCXCR3CCR5KMT2A | |
| SCHEMBL6012245 | 0.91 | POLB (0.58) | POLBKMT2AMEN1 | |
| SCHEMBL6615583 | 0.89 | POLB (0.55) | POLBKMT2AMEN1 | |
| SCHEMBL6611478 | 0.88 | CXCR3 (0.66) | CXCR3CCR5 | |
| SCHEMBL6618147 | 0.86 | CXCR3 (0.70) | CXCR3CCR5KMT2A | |
| SCHEMBL6613676 | 0.85 | CXCR3 (0.58) | CXCR3CCR5KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119091-B2 | Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-10-10 | — | — | US | disclosed |
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |