Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29362288 | 1.00 | HDAC1 (0.48) | HDAC1HDAC6SMN1; SMN2CYP11B2GAA | |
| SCHEMBL28604201 | 0.95 | AVPR2 (0.48) | HDAC1HDAC6SMN1; SMN2CYP11B2GAA | |
| SCHEMBL29736751 | 0.90 | CRBN (0.51) | HDAC1HDAC6SMN1; SMN2CYP11B2MEN1 | |
| SCHEMBL18181423 | 0.90 | CRBN (0.51) | HDAC1HDAC6SMN1; SMN2CYP11B2MEN1 | |
| SCHEMBL29489948 | 0.86 | CYP11B2 (0.61) | CYP11B2 | |
| SCHEMBL16671108 | 0.86 | CYP11B2 (0.61) | CYP11B2 | |
| Hydrochloric Acid SCHEMBL30640657 | 0.84 | CYP11B2 (0.60) | CYP11B2 | |
| SCHEMBL32676351 | 0.80 | MAPT (0.57) | SMN1; SMN2GAAMEN1KMT2APOLB | |
| SCHEMBL25921151 | 0.79 | CYP11B2 (0.45) | HDAC1HDAC6SMN1; SMN2CYP11B2GAA | |
| SCHEMBL861264 | 0.79 | POLB (0.45) | HDAC1HDAC6CYP11B2GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684754-A1 | HMG-COA REDUCTASE INHIBITORS AND METHOD | Bristol-Myers Squibb Company (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051386-A1 | HMG-COA REDUCTASE INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |