Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | GCGR | P47871 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201704 | 0.84 | ADORA2A (0.43) | SCN9AGCGRMAPK14 | |
| SCHEMBL12299835 | 0.76 | NOS3 (0.39) | HTR2B | |
| SCHEMBL17341047 | 0.74 | MAPK10 (0.43) | CYP17A1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12202948 | 0.71 | ADORA3 (0.41) | GCGRALDH1A3HTR2B | |
| SCHEMBL12228276 | 0.71 | KDM4E (0.45) | SCN9AHTR2B | |
| SCHEMBL28094104 | 0.70 | NOS3 (0.44) | SCN9AHTR2B | |
| SCHEMBL2337367 | 0.70 | ADORA3 (0.43) | SCN9AGCGR | |
| SCHEMBL3840856 | 0.70 | AURKA (0.56) | HTR2BMAPK14 | |
| SCHEMBL18086893 | 0.70 | CYP17A1 (0.40) | GCGRCYP17A1MAPK14MAPK13MAPK12 | |
| SCHEMBL16282388 | 0.70 | NOS3 (0.57) | HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684754-A1 | HMG-COA REDUCTASE INHIBITORS AND METHOD | Bristol-Myers Squibb Company (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051386-A1 | HMG-COA REDUCTASE INHIBITORS AND METHOD | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-06-09 | — | — | WO | disclosed |