Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HEXA | P06865 | 1/20 | 0.36 |
| ▸ | HEXB | P07686 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1080759 | 0.83 | MAPK1 (0.42) | KMOMAPK1HSD17B10MAPTALDH1A1 | |
| SCHEMBL28448801 | 0.81 | RECQL (0.54) | KMONR4A3NR4A1NR4A2HSD17B10 | |
| SCHEMBL2585360 | 0.78 | DHODH (0.46) | DHODHNR4A3NR4A1NR4A2HSD17B10 | |
| SCHEMBL29520867 | 0.78 | DHODH (0.46) | DHODHNR4A3NR4A1NR4A2HSD17B10 | |
| SCHEMBL12900334 | 0.77 | TSHR (0.49) | KMOHSD17B10MAPTSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6809142 | 0.76 | DHODH (0.44) | DHODHNR4A3NR4A1NR4A2HSD17B10 | |
| SCHEMBL20541605 | 0.76 | EGLN1 (0.49) | DHODHALDH1A1RECQL | |
| SCHEMBL21506587 | 0.76 | RECQL (0.42) | KMOALDH1A1RECQL | |
| SCHEMBL26603232 | 0.76 | FABP4 (0.48) | KMOHSD17B10MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL30547754 | 0.76 | KMO (0.43) | KMONR4A3NR4A1NR4A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459563-A2 | 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF | Albany Molecular Research, Inc. (US) | 2012-06-06 | — | — | EP | disclosed |
| EP-1651640-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | Pfizer Limited (GB) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005009994-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |