Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013545 | 1.00 | MEN1 (0.37) | MEN1KMT2AGAATAS2R14ALDH1A1 | |
| SCHEMBL5025675 | 0.84 | TAS2R14 (0.38) | MEN1KMT2AGAATAS2R14ALDH1A1 | |
| SCHEMBL5025673 | 0.84 | TAS2R14 (0.38) | MEN1KMT2AGAATAS2R14ALDH1A1 | |
| SCHEMBL5024111 | 0.76 | PLG (0.35) | MEN1KMT2AGAATAS2R14ALDH1A1 | |
| SCHEMBL5028495 | 0.76 | PLG (0.35) | MEN1KMT2AGAATAS2R14ALDH1A1 | |
| SCHEMBL5025729 | 0.73 | JAK2 (0.37) | ALDH1A1CYP4F2CYP4A11POLB | |
| SCHEMBL5025727 | 0.73 | JAK2 (0.37) | ALDH1A1CYP4F2CYP4A11POLB | |
| SCHEMBL1292139 | 0.72 | VCP (0.53) | — | |
| SCHEMBL5025534 | 0.72 | TAS2R14 (0.40) | MEN1KMT2AGAATAS2R14ALDH1A1 | |
| SCHEMBL5025529 | 0.72 | TAS2R14 (0.40) | MEN1KMT2AGAATAS2R14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667962-A1 | AMINOALKYLAMIDE SUBSTITUTED CYCLOHEXYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005028427-A1 | AMINOALKYLAMIDE SUBSTITUTED CYCLOHEXYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-31 | — | — | WO | disclosed |