Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274253 | 0.90 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9ATSHRMAPTMAPK1 | |
| SCHEMBL10898616 | 0.83 | HPGD (0.51) | SMN1; SMN2HPGDNPSR1RAB9ANPC1 | |
| SCHEMBL8163196 | 0.82 | CA12 (0.47) | HPGDTSHRMAPTMAPK1ALDH1A1 | |
| SCHEMBL11406567 | 0.80 | HPGD (0.49) | SMN1; SMN2HPGDNPSR1RAB9ANPC1 | |
| SCHEMBL11296757 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2GLABRCA1HPGDNPSR1 | |
| SCHEMBL3642366 | 0.78 | RAB9A (0.65) | SMN1; SMN2GLABRCA1HPGDNPSR1 | |
| SCHEMBL29530672 | 0.78 | RAB9A (0.65) | SMN1; SMN2GLABRCA1HPGDNPSR1 | |
| SCHEMBL25991266 | 0.77 | HPGD (0.61) | SMN1; SMN2GLABRCA1HPGDNPSR1 | |
| SCHEMBL2743018 | 0.77 | HPGD (0.61) | SMN1; SMN2GLABRCA1HPGDNPSR1 | |
| SCHEMBL9242647 | 0.77 | TSHR (0.56) | SMN1; SMN2RAB9ANPC1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718150-A1 | METHYLATION INHIBITOR COMPOUNDS | The Government of the United States of America, represented by the Secretary, Department of Health and Human Services (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005082144-A1 | METHYLATION INHIBITOR COMPOUNDS | GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER (US) | 2005-09-09 | — | — | WO | disclosed |
| WO-2005080406-A2 | COMPOUNDS FOR THE INHIBITION OF UNDESIRED CELL PROLIFERATION AND USE THEREOF | JERINI AG (DE) | 2005-09-01 | — | — | WO | disclosed |
| US-3985875-A | RENIN INHIBITION, ANTIHYPERTENSIVE, ANTICHOLESTEROL AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JA) | 1976-10-12 | — | — | US | disclosed |