Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620123 | 0.82 | KDR (0.67) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL27823104 | 0.81 | MLYCD (0.56) | RAB9ANPC1SMN1; SMN2PDK1TRPV1 | |
| SCHEMBL16628055 | 0.80 | RAF1 (0.63) | TRPV1RAF1MEN1KMT2ABRAF | |
| SCHEMBL10222082 | 0.79 | KDR (0.59) | PDK1TRPV1RAF1MEN1KMT2A | |
| SCHEMBL1513766 | 0.78 | CETP (0.44) | CETPPDK2MEN1KMT2ATSHR | |
| SCHEMBL11810258 | 0.78 | LMNA (0.54) | SMN1; SMN2KMT2ATSHRMAPTALDH1A1 | |
| SCHEMBL403261 | 0.78 | CA12 (0.51) | RAB9ATP53MAPTBRAFALDH1A1 | |
| SCHEMBL16628095 | 0.75 | TRPV1 (0.65) | PDK1TRPV1RAF1 | |
| SCHEMBL12020252 | 0.75 | RAF1 (0.61) | RAF1MEN1KMT2ABRAFHDAC1 | |
| SCHEMBL19668025 | 0.72 | MEN1 (0.61) | SMN1; SMN2RAF1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298311-B1 | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-09 | — | — | EP | disclosed |