Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | PTGIR | P43119 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5442115 | 0.91 | SLC6A2 (0.39) | SPHK1IGF1RBTKJAK2JAK1 | |
| SCHEMBL5437301 | 0.91 | IGF1R (0.40) | SPHK1IGF1RBTKJAK2JAK1 | |
| SCHEMBL2460551 | 0.85 | IGF1R (0.48) | SPHK1IGF1RKCNH2SPHK2BTK | |
| SCHEMBL2459807 | 0.84 | IGF1R (0.47) | SPHK1IGF1RKCNH2SPHK2JAK2 | |
| SCHEMBL2457374 | 0.83 | IGF1R (0.43) | IGF1RKCNH2JAK2JAK1MRGPRX4 | |
| SCHEMBL6014584 | 0.82 | SLC6A2 (0.39) | SPHK1IGF1RSPHK2JAK2JAK1 | |
| SCHEMBL2460636 | 0.81 | IGF1R (0.39) | IGF1RMRGPRX4 | |
| SCHEMBL2460257 | 0.80 | IGF1R (0.40) | SPHK1IGF1RSPHK2 | |
| SCHEMBL3537676 | 0.80 | MRGPRX4 (0.42) | SPHK1SPHK2BTKJAK2DHODH | |
| SCHEMBL2458133 | 0.80 | IGF1R (0.41) | IGF1RJAK2JAK1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-A2 | IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037836-A2 | IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |