Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | PTGIR | P43119 | 2/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | CPT1A | P50416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5442115 | 0.91 | SLC6A2 (0.39) | SLC6A2SLC6A4JAK2JAK1IGF1R | |
| SCHEMBL2460497 | 0.86 | JAK2 (0.40) | JAK2JAK1IGF1RHDAC4MRGPRX4 | |
| SCHEMBL2459920 | 0.85 | IGF1R (0.38) | JAK2JAK1IGF1RHDAC4MRGPRX4 | |
| SCHEMBL5437301 | 0.82 | IGF1R (0.40) | JAK2JAK1IGF1RRAB9AHDAC4 | |
| SCHEMBL6014676 | 0.82 | SPHK1 (0.39) | JAK2JAK1IGF1RSPHK1MRGPRX4 | |
| SCHEMBL2460301 | 0.81 | IGF1R (0.35) | JAK2JAK1IGF1RALOX5 | |
| SCHEMBL2459426 | 0.80 | BRD4 (0.36) | JAK2JAK1HDAC4MRGPRX4 | |
| SCHEMBL2463487 | 0.79 | PRMT5 (0.38) | IGF1RRAB9AALOX5SPHK1SPHK2 | |
| SCHEMBL2459738 | 0.79 | MAOB (0.37) | JAK2JAK1IGF1RHDAC4MRGPRX4 | |
| SCHEMBL2462099 | 0.79 | IGF1R (0.39) | JAK2JAK1IGF1RALOX5SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675860-A2 | IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037836-A2 | IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |