Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CPB1 | P15086 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5437301 | 0.92 | IGF1R (0.40) | IGF1RJAK2JAK1RAB9AHDAC4 | |
| SCHEMBL6014676 | 0.91 | SPHK1 (0.39) | IGF1RJAK2JAK1DHODHBTK | |
| SCHEMBL6014584 | 0.91 | SLC6A2 (0.39) | SLC6A2SLC6A4IGF1RJAK2JAK1 | |
| SCHEMBL2458133 | 0.86 | IGF1R (0.41) | IGF1RJAK2JAK1HDAC4DHODH | |
| SCHEMBL5139012 | 0.81 | SLC6A2 (0.43) | SLC6A2SLC6A4IGF1RALOX5 | |
| SCHEMBL2457374 | 0.81 | IGF1R (0.43) | IGF1RJAK2JAK1 | |
| SCHEMBL2463470 | 0.81 | IGF1R (0.51) | IGF1RJAK2JAK1HDAC4 | |
| SCHEMBL2460551 | 0.80 | IGF1R (0.48) | IGF1RJAK2JAK1RAB9ABTK | |
| SCHEMBL2459690 | 0.80 | IGF1R (0.37) | IGF1RALOX5 | |
| SCHEMBL2460657 | 0.80 | ADAM17 (0.39) | IGF1RJAK2JAK1HDAC4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509060-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675860-A2 | IMIDAZO[1,5-A]PYRAZINE TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005037836-A2 | IMIDAZO ‘1, 5 - A ! PYRAZINE TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | claimed |