Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14538979 | 0.89 | AR (0.49) | PARP10SMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL258010 | 0.84 | BRAF (0.58) | SMN1; SMN2MAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL31295589 | 0.83 | ALDH1A1 (0.58) | MAPTHTTALDH1A1MEN1GAA | |
| SCHEMBL623759 | 0.83 | ALDH1A1 (0.58) | MAPTHTTALDH1A1MEN1GAA | |
| SCHEMBL1086016 | 0.83 | MAPT (0.66) | PARP10MAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL30052013 | 0.83 | MAPT (0.66) | PARP10MAPTHTTNPSR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15486584 | 0.82 | ALDH1A1 (0.56) | MAPTHTTALDH1A1TDP1POLB | |
| Hydrochloric Acid SCHEMBL27585316 | 0.82 | MAPT (0.64) | PARP10MAPTHTTNPSR1ALDH1A1 | |
| SCHEMBL177818 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2MAPTTEAD4ALDH1A1TDP1 | |
| SCHEMBL31557923 | 0.81 | PARP10 (0.56) | PARP10SMN1; SMN2MAPTTEAD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298311-B1 | w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors | BAYER HEALTHCARE LLC (US) | 2012-05-09 | — | — | EP | disclosed |