Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015280 | 0.88 | CHEK1 (0.48) | CHEK1CDK2AP1 | |
| SCHEMBL5555715 | 0.85 | PIN1 (0.47) | CHEK1 | |
| SCHEMBL1564649 | 0.84 | CHEK1 (0.71) | CHEK1CDK2AP1 | |
| SCHEMBL6015302 | 0.82 | CHEK1 (0.49) | CHEK1CDK2AP1 | |
| SCHEMBL6015228 | 0.81 | CHEK1 (0.47) | CHEK1CDK2AP1 | |
| SCHEMBL6015241 | 0.81 | CHEK1 (0.47) | CHEK1CDK2AP1 | |
| SCHEMBL6015254 | 0.80 | CHEK1 (0.42) | CHEK1CDK2AP1 | |
| SCHEMBL6015237 | 0.76 | KDM4E (0.49) | CHEK1CDK2AP1 | |
| SCHEMBL6015246 | 0.75 | CHEK1 (0.48) | CHEK1CDK2AP1 | |
| SCHEMBL1563775 | 0.72 | CHEK1 (0.66) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |