Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015772 | 0.86 | HPGD (0.51) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL6016003 | 0.78 | TLR7 (0.36) | KMT2AMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7646046 | 0.77 | HPGD (0.40) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL6015704 | 0.72 | PDE3B (0.51) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL6015731 | 0.68 | MAPT (0.44) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL24163542 | 0.67 | HPGD (1.00) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL6015641 | 0.65 | PDE3B (0.46) | HPGDKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL7372119 | 0.64 | HPGD (0.58) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL3160508 | 0.64 | RAB9A (0.59) | HPGDKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL6015878 | 0.62 | TSHR (0.51) | ALDH1A1CYP1A2CYP2D6CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |