Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015641 | 0.85 | PDE3B (0.46) | PDE3BPDE3AHPGDKMT2AALDH1A1 | |
| SCHEMBL6015753 | 0.80 | PDE3B (0.58) | PDE3BPDE3AHPGDKMT2AALDH1A1 | |
| SCHEMBL6015910 | 0.77 | PDE3B (0.49) | PDE3BPDE3AKMT2AALDH1A1CYP1A2 | |
| SCHEMBL6015947 | 0.75 | POLB (0.53) | HPGDKMT2AMEN1TSHRPOLB | |
| SCHEMBL6015805 | 0.72 | LTA4H (0.56) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6015812 | 0.72 | HPGD (0.50) | PDE3BPDE3AHPGDKMT2AALDH1A1 | |
| SCHEMBL6015872 | 0.71 | LTA4H (0.55) | KMT2APOLB | |
| SCHEMBL6016063 | 0.71 | LTA4H (0.55) | KMT2APOLB | |
| SCHEMBL3160508 | 0.71 | RAB9A (0.59) | PDE3BPDE3AHPGDKMT2AALDH1A1 | |
| SCHEMBL6015772 | 0.71 | HPGD (0.51) | PDE3BPDE3AHPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | claimed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | claimed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | claimed |
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |