Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.62 |
| ▸ | RET | P07949 | 3/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.62 |
| ▸ | ABL1 | P00519 | 3/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.62 |
| ▸ | LTK | P29376 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | FLT3 | P36888 | 2/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.62 |
| ▸ | CDK7 | P50613 | 2/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.62 |
| ▸ | MST1R | Q04912 | 2/20 | 0.62 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.62 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016053 | 0.82 | CHEK1 (0.66) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL1980862 | 0.77 | NTRK1 (1.00) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL14448886 | 0.77 | NTRK1 (1.00) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL1980864 | 0.77 | NTRK1 (1.00) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL30665394 | 0.75 | NTRK1 (0.63) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL1428998 | 0.73 | MAPT (0.51) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL4324777 | 0.73 | MAPT (0.51) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL1520549 | 0.73 | NTRK1 (0.69) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL7149051 | 0.73 | NTRK1 (0.64) | NTRK1RETPRKD3ABL1PDGFRB | |
| SCHEMBL7149059 | 0.73 | NTRK1 (0.64) | NTRK1RETPRKD3ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | disclosed |