Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.66 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015962 | 0.82 | NTRK1 (0.62) | CHEK1KMT2ACDK1NTRK1DAPK3 | |
| SCHEMBL857064 | 0.80 | CHEK1 (1.00) | CHEK1HASPINCCNT1CDK9KMT2A | |
| SCHEMBL8464120 | 0.80 | CHEK1 (1.00) | CHEK1HASPINCCNT1CDK9KMT2A | |
| SCHEMBL8464117 | 0.80 | CHEK1 (1.00) | CHEK1HASPINCCNT1CDK9KMT2A | |
| SCHEMBL6288779 | 0.78 | CHEK1 (0.76) | CHEK1HASPINCCNT1CDK9KMT2A | |
| SCHEMBL6288777 | 0.78 | CHEK1 (0.76) | CHEK1HASPINCCNT1CDK9KMT2A | |
| SCHEMBL6090414 | 0.73 | CHEK1 (0.61) | CHEK1HASPINCCNT1CDK9KMT2A | |
| SCHEMBL6090410 | 0.73 | CHEK1 (0.61) | CHEK1HASPINCCNT1CDK9KMT2A | |
| SCHEMBL7549754 | 0.72 | NTRK1 (0.71) | CHEK1CHEK2CDK1SRCCSNK2A2 | |
| SCHEMBL7549757 | 0.72 | NTRK1 (0.71) | CHEK1CHEK2CDK1SRCCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |
| EP-1181282-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000075139-A2 | BENZOTHIAZINONE AND BENZOXAZINONE COMPOUNDS | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-14 | — | — | WO | disclosed |