Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | SNCA | P37840 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6015684 | 0.81 | APP (0.39) | APPSNCANPC1RAB9AALDH1A1 | |
| SCHEMBL15546774 | 0.77 | POLB (0.39) | APPSNCANPC1RAB9AKMT2A | |
| SCHEMBL7619956 | 0.76 | KMT2A (0.40) | APPSNCANPC1RAB9AKMT2A | |
| SCHEMBL31516345 | 0.76 | CNR1 (0.44) | APPSNCANPC1RAB9AKMT2A | |
| SCHEMBL89569 | 0.73 | GSK3B (0.53) | NPC1RAB9AL3MBTL1ALDH1A1POLB | |
| SCHEMBL19410208 | 0.73 | ALDH1A1 (0.46) | APPSNCANPC1RAB9AKMT2A | |
| SCHEMBL6090127 | 0.73 | CNR2 (0.50) | APPSNCANPC1RAB9AKMT2A | |
| SCHEMBL12252047 | 0.72 | APP (0.65) | APPSNCAKMT2AL3MBTL1MEN1 | |
| SCHEMBL6087986 | 0.71 | CNR1 (0.44) | NPC1RAB9AALDH1A1CNR1CNR2 | |
| SCHEMBL413483 | 0.70 | KMT2A (0.41) | APPSNCANPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049312-B1 | Benzothiazinone and benzoxazinone compounds | ABBOTT GMBH & CO. KG (DE) | 2006-05-23 | — | — | US | disclosed |