Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.48 |
| ▸ | AURKA | O14965 | 6/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3857488 | 0.90 | SYK (0.53) | SYKAURKACDK1GRM4 | |
| SCHEMBL6016759 | 0.89 | SYK (0.49) | SYKAURKACDK1GRM4 | |
| SCHEMBL6016199 | 0.87 | SYK (0.52) | SYKAURKACDK1TRPA1GRM4 | |
| SCHEMBL6016437 | 0.85 | SYK (0.59) | SYKAURKACDK1 | |
| SCHEMBL6016293 | 0.84 | SYK (0.45) | SYKAURKACDK1KCNQ3KCNQ2 | |
| SCHEMBL6016171 | 0.84 | GRM4 (0.50) | SYKAURKACDK1TRPA1GRM4 | |
| SCHEMBL6016596 | 0.83 | SYK (0.68) | SYKAURKA | |
| SCHEMBL4935260 | 0.83 | SYK (0.68) | SYKAURKA | |
| SCHEMBL6016323 | 0.82 | SYK (0.58) | SYKAURKACDK1 | |
| SCHEMBL6016128 | 0.81 | SYK (0.69) | SYKAURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |