Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.45 |
| ▸ | BCL6 | P41182 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101241 | 0.86 | SYK (0.61) | SYKAURKA | |
| SCHEMBL3089169 | 0.84 | SYK (0.55) | SYKBCL6 | |
| SCHEMBL6016263 | 0.84 | SYK (0.48) | SYKAURKACDK1KCNQ3KCNQ2 | |
| SCHEMBL6016290 | 0.83 | SYK (0.47) | SYK | |
| SCHEMBL6016192 | 0.83 | SYK (0.62) | SYKCDK1 | |
| SCHEMBL6016685 | 0.83 | SYK (0.63) | SYKAURKA | |
| SCHEMBL6016259 | 0.83 | SYK (0.62) | SYKAURKA | |
| SCHEMBL6016765 | 0.80 | SYK (0.63) | SYKAURKA | |
| SCHEMBL6016269 | 0.80 | SYK (0.63) | SYKAURKA | |
| SCHEMBL6016150 | 0.79 | SYK (0.62) | SYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |