Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016118 | 0.92 | SYK (0.48) | SYKCCNT1CCNE1CDK2CDK9 | |
| SCHEMBL6016262 | 0.88 | SYK (0.63) | SYK | |
| SCHEMBL6016266 | 0.87 | SYK (0.56) | SYKEGFRITK | |
| SCHEMBL6016638 | 0.86 | SYK (0.55) | SYKCCNT1CCNE1CDK2CDK9 | |
| SCHEMBL6016309 | 0.86 | SYK (0.56) | SYKEGFRITK | |
| SCHEMBL6016430 | 0.85 | SYK (0.55) | SYKEGFR | |
| SCHEMBL6016130 | 0.85 | SYK (0.55) | SYKEGFR | |
| SCHEMBL6016293 | 0.83 | SYK (0.45) | SYK | |
| SCHEMBL6016537 | 0.81 | SYK (0.63) | SYK | |
| SCHEMBL6016263 | 0.80 | SYK (0.48) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |