Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016417 | 0.88 | HSP90AB1 (0.52) | RXFP1MAPTMEN1KMT2ATHRB | |
| SCHEMBL6016509 | 0.84 | RXFP1 (0.42) | RXFP1MAPTTHRBPOLBLMNA | |
| SCHEMBL6016328 | 0.82 | RXFP1 (0.53) | RXFP1MAPTMEN1KMT2ATHRB | |
| SCHEMBL6016560 | 0.80 | EIF4E (0.42) | MAPTMEN1KMT2AEIF4ELMNA | |
| SCHEMBL6016291 | 0.79 | RXFP1 (0.62) | RXFP1MAPTTHRBPOLBPDE4B | |
| SCHEMBL27549124 | 0.77 | EIF4E (0.40) | EIF4EHTTGAAGFER | |
| SCHEMBL6016535 | 0.77 | RXFP1 (0.50) | RXFP1MAPTMEN1KMT2ATHRB | |
| SCHEMBL6016413 | 0.75 | TACR1 (0.43) | MAPTKMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL6016511 | 0.75 | GPBAR1 (0.40) | RXFP1MAPTLMNAHTTMAPK1 | |
| SCHEMBL6016492 | 0.74 | PAICS (0.41) | MEN1KMT2AEIF4EMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | disclosed |
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |