Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 9/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016381 | 0.85 | RXFP1 (0.56) | RXFP1MAPTTHRBNTRK1NPC1 | |
| SCHEMBL6016328 | 0.84 | RXFP1 (0.53) | RXFP1MAPTTHRBNTRK1POLB | |
| SCHEMBL6016488 | 0.84 | RXFP1 (0.48) | RXFP1MAPTTHRBNTRK1TP53 | |
| SCHEMBL2953742 | 0.83 | ALDH1A1 (0.58) | MAPTNPC1RAB9APOLBALDH1A1 | |
| SCHEMBL6016353 | 0.83 | THRB (0.49) | RXFP1MAPTTHRBNTRK1TP53 | |
| SCHEMBL6016647 | 0.82 | RXFP1 (0.44) | RXFP1MAPTTHRB | |
| SCHEMBL6016587 | 0.82 | MAPT (0.50) | RXFP1MAPTTHRBNTRK1DHODH | |
| SCHEMBL6016541 | 0.81 | THRB (0.66) | RXFP1MAPTTHRBNTRK1TP53 | |
| SCHEMBL6016417 | 0.79 | HSP90AB1 (0.52) | RXFP1MAPTTHRBNTRK1DHODH | |
| SCHEMBL30395416 | 0.79 | NPC1 (0.52) | NPC1RAB9ADHODHPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | disclosed |
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |