Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 2/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.35 |
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016360 | 0.92 | RXFP1 (0.44) | RXFP1LMNAMAPTGPBAR1THRB | |
| SCHEMBL7991781 | 0.90 | EPAS1 (0.43) | RXFP1LMNATHRBTACR1POLB | |
| SCHEMBL6016482 | 0.87 | RXFP1 (0.55) | RXFP1LMNAMAPTTHRBTACR1 | |
| SCHEMBL6016647 | 0.85 | RXFP1 (0.44) | RXFP1LMNAMAPTGPBAR1THRB | |
| SCHEMBL6016440 | 0.84 | RXFP1 (0.49) | RXFP1LMNAMAPTTHRBPOLB | |
| SCHEMBL6016692 | 0.84 | TACR1 (0.46) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL7991077 | 0.83 | RXFP1 (0.42) | RXFP1MAPTTHRBTACR1 | |
| SCHEMBL6016386 | 0.82 | RXFP1 (0.45) | RXFP1LMNAMAPTTHRBTACR1 | |
| SCHEMBL6016511 | 0.80 | GPBAR1 (0.40) | RXFP1LMNAMAPTGPBAR1TACR1 | |
| SCHEMBL6016417 | 0.76 | HSP90AB1 (0.52) | RXFP1MAPTTHRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | disclosed |
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |