Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 16/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 4/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6873362 | 0.89 | TACR1 (0.51) | TACR1SYKTACR3GPBAR1 | |
| SCHEMBL6016707 | 0.86 | TACR1 (0.50) | TACR1TACR3GPBAR1 | |
| SCHEMBL6016667 | 0.85 | TACR1 (0.49) | TACR1TACR3GPBAR1LIPE | |
| SCHEMBL6870600 | 0.82 | CETP (0.50) | TACR1SYKGPBAR1 | |
| SCHEMBL6862336 | 0.82 | TACR1 (0.51) | TACR1SYKGPBAR1 | |
| SCHEMBL7045412 | 0.81 | SYK (0.43) | TACR1SYKLIPE | |
| SCHEMBL6016586 | 0.79 | TACR1 (0.64) | TACR1 | |
| SCHEMBL6871465 | 0.78 | TACR1 (0.49) | TACR1TACR3GPBAR1 | |
| SCHEMBL6016479 | 0.78 | TACR1 (0.53) | TACR1 | |
| SCHEMBL6016604 | 0.78 | TACR1 (0.53) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | claimed |