SCHEMBL6016586

SCHEMBL6016586

CN1CCN(c2ncc(OC(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(-c3ccccc3Cl)n2)CC1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 19/20 0.64
MET P08581 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6016479 0.91 TACR1 (0.53) TACR1
SCHEMBL6016604 0.91 TACR1 (0.53) TACR1
SCHEMBL6016649 0.91 TACR1 (0.77) TACR1
SCHEMBL6016699 0.91 TACR1 (0.65) TACR1
SCHEMBL6016733 0.91 TACR1 (0.65) TACR1
SCHEMBL6016428 0.91 TACR1 (0.64) TACR1
SCHEMBL6016646 0.90 TACR1 (0.63) TACR1
SCHEMBL6868287 0.89 TACR1 (0.63) TACR1MET
SCHEMBL17476477 0.87 TACR1 (0.83) TACR1
SCHEMBL6016483 0.87 TACR1 (0.48) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187815-B1 4-PHENYL-PYRIMIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2006-02-08 EP claimed