Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016364 | 0.94 | ALDH1A1 (0.47) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6016503 | 0.86 | KDM4E (0.41) | LSSKDM4EALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL6016402 | 0.85 | MAPK14 (0.43) | KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6016394 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6016572 | 0.79 | MAPK14 (0.48) | KMT2AKDM4EALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL6016481 | 0.78 | ALDH1A1 (0.49) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6016508 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1SMN1; SMN2ATMHRH3 | |
| SCHEMBL6016450 | 0.78 | MEN1 (0.51) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6016703 | 0.78 | MAPK14 (0.39) | MEN1KMT2AKDM4EALDH1A1ATM | |
| SCHEMBL7704154 | 0.77 | KDM4E (0.40) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-B1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2006-02-08 | — | — | EP | disclosed |
| CN-1166643-C | 4-phenyl-pyrimidine derivatives | - | 2004-09-15 | — | — | CN | disclosed |
| CN-1353697-A | 4-phenyl-pyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 2002-06-12 | — | — | CN | disclosed |
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| US-6274588-B1 | NEUROKININ OR SUBSTANCE P ANTAGONISTS; CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDES; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-14 | — | — | US | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |