Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016865 | 0.94 | NR1H4 (0.56) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5961347 | 0.89 | NR1H4 (0.51) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6016986 | 0.89 | NR1H4 (0.51) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5961309 | 0.87 | NPC1 (0.50) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6016948 | 0.84 | NR1H4 (0.52) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5961407 | 0.82 | RAB9A (0.56) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6886843 | 0.81 | KMT2A (0.49) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL5961335 | 0.81 | NR1H4 (0.48) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6017005 | 0.81 | RAB9A (0.57) | NR1H4KMT2AMEN1NPC1RAB9A | |
| SCHEMBL6016950 | 0.80 | NR1H4 (0.59) | NR1H4KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |