Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6016969 | 0.89 | RAB9A (0.57) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL5961315 | 0.84 | RAB9A (0.58) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL6886123 | 0.81 | RAB9A (0.61) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL6016795 | 0.81 | NR1H4 (0.52) | RAB9ANPC1KMT2AMEN1NR1H4 | |
| SCHEMBL5961407 | 0.81 | RAB9A (0.56) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL5961396 | 0.80 | RAB9A (0.50) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL1009855 | 0.79 | PTGDR2 (0.58) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL27634955 | 0.78 | RAB9A (0.52) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL12569065 | 0.77 | RAB9A (0.52) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL5961319 | 0.77 | RAB9A (0.47) | RAB9ANPC1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |