Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | MMP1 | P03956 | 6/20 | 0.46 |
| ▸ | MMP2 | P08253 | 6/20 | 0.46 |
| ▸ | MMP9 | P14780 | 6/20 | 0.46 |
| ▸ | ACHE | P22303 | 5/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1652115 | 0.84 | PTGDR2 (0.54) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL1652116 | 0.84 | PTGDR2 (0.54) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL1652753 | 0.83 | MAPT (0.48) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL1012128 | 0.80 | PTGDR2 (0.58) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL1009825 | 0.80 | PTGDR2 (0.58) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL6886098 | 0.78 | MAPT (0.46) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL1652155 | 0.78 | TBXA2R (0.51) | RAB9APTGDR2 | |
| SCHEMBL2008263 | 0.78 | PTGDR2 (0.56) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL2008264 | 0.78 | PTGDR2 (0.56) | EGFRMMP1MMP2MMP9ACHE | |
| SCHEMBL1009325 | 0.77 | PTGDR2 (0.57) | EGFRMMP1MMP2MMP9ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |