Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961317 | 0.89 | EPHX2 (0.41) | GAAPOLBEPHX2NPC1RAB9A | |
| SCHEMBL6016869 | 0.86 | GAA (0.40) | GAAPOLBEPHX2SMN1; SMN2TSHR | |
| SCHEMBL5961320 | 0.84 | EPHX1 (0.41) | GAAEPHX2ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL6017031 | 0.83 | GAA (0.42) | GAAPOLBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5961338 | 0.83 | TBXA2R (0.40) | POLBALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL5961348 | 0.82 | HDAC1 (0.43) | GAAPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6016968 | 0.82 | ACKR3 (0.40) | GAAEPHX2SMN1; SMN2AURKBMEN1 | |
| SCHEMBL5961316 | 0.81 | EPHX1 (0.42) | HPGD | |
| SCHEMBL5961345 | 0.81 | ACKR3 (0.42) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6016975 | 0.80 | EPHX2 (0.43) | GAAPOLBEPHX2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |