Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961320 | 0.86 | EPHX1 (0.41) | GAAEPHX1EPHX2SMN1; SMN2TSHR | |
| SCHEMBL6016878 | 0.86 | GAA (0.39) | GAAPOLBEPHX2HDAC1HDAC6 | |
| SCHEMBL5961317 | 0.85 | EPHX2 (0.41) | GAAEPHX1POLBEPHX2RAB9A | |
| SCHEMBL6017031 | 0.84 | GAA (0.42) | GAAEPHX1POLBHDAC1HDAC6 | |
| SCHEMBL5961338 | 0.84 | TBXA2R (0.40) | POLBHDAC1HDAC6SMN1; SMN2RAB9A | |
| SCHEMBL5961348 | 0.83 | HDAC1 (0.43) | GAAEPHX1POLBHDAC1HDAC6 | |
| SCHEMBL5961316 | 0.82 | EPHX1 (0.42) | EPHX1HPGD | |
| SCHEMBL6016975 | 0.81 | EPHX2 (0.43) | GAAEPHX1POLBEPHX2SMN1; SMN2 | |
| SCHEMBL6016968 | 0.81 | ACKR3 (0.40) | GAAEPHX2SMN1; SMN2HPGDMEN1 | |
| SCHEMBL5961329 | 0.81 | RAB9A (0.46) | SMN1; SMN2TSHRRAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |