Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961348 | 0.94 | HDAC1 (0.43) | GAAPOLBTBXA2RPTGDRPTGDR2 | |
| SCHEMBL5961338 | 0.93 | TBXA2R (0.40) | POLBTBXA2RPTGDRPTGDR2ACKR3 | |
| SCHEMBL6016975 | 0.92 | EPHX2 (0.43) | GAAPOLBACKR3NPC1EPHX1 | |
| SCHEMBL6016947 | 0.90 | KMT2A (0.41) | POLBPTGDR2ACKR3NPC1RAB9A | |
| SCHEMBL5961345 | 0.89 | ACKR3 (0.42) | POLBPTGDR2ACKR3NPC1RAB9A | |
| SCHEMBL5961320 | 0.86 | EPHX1 (0.41) | GAAALDH1A1NPC1EPHX1CYP2C9 | |
| SCHEMBL5961317 | 0.86 | EPHX2 (0.41) | GAAPOLBACKR3NPC1EPHX1 | |
| SCHEMBL6016971 | 0.85 | HDAC1 (0.44) | GAAPTGDR2ACKR3ALDH1A1NPC1 | |
| SCHEMBL6016869 | 0.84 | GAA (0.40) | GAAPOLBNPC1EPHX1RAB9A | |
| SCHEMBL5961329 | 0.84 | RAB9A (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471057-A1 | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 | Bayer HealthCare AG (DE) | 2004-10-27 | — | — | EP | claimed |
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |