Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.56 |
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656149 | 0.88 | SYK (0.59) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL656938 | 0.86 | AURKA (0.57) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL656514 | 0.83 | BRD4 (0.57) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL655411 | 0.83 | ALDH1A1 (0.61) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL3854812 | 0.80 | SYK (0.50) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL655917 | 0.78 | SYK (0.64) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL653941 | 0.75 | SYK (0.47) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL30948594 | 0.75 | ABCG2 (0.46) | SYKAURKACDK1GSK3BSTK17A | |
| SCHEMBL657103 | 0.74 | SYK (0.74) | SYKAURKACDK1GSK3BKDR | |
| SCHEMBL31684791 | 0.74 | PIN1 (0.54) | SYKCDK1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |