Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1652165 | 0.87 | PTGDR2 (0.40) | EGFRMCHR1ACHEBCHEMAOA | |
| SCHEMBL1652160 | 0.87 | PTGDR2 (0.40) | EGFRMCHR1ACHEBCHEMAOA | |
| SCHEMBL1652406 | 0.80 | PTGDR2 (0.44) | EGFRMCHR1ACHEBCHEMAOA | |
| SCHEMBL1652412 | 0.80 | PTGDR2 (0.44) | EGFRMCHR1ACHEBCHEMAOA | |
| SCHEMBL6886098 | 0.77 | MAPT (0.46) | EGFRMCHR1ACHEBCHERAB9A | |
| SCHEMBL2009570 | 0.73 | PTGDR2 (0.46) | RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL1009817 | 0.71 | PTGDR2 (0.38) | MCHR1LMNAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1651355 | 0.71 | PTGDR2 (0.48) | EGFRACHEBCHEMAOAMAOB | |
| SCHEMBL1651358 | 0.71 | PTGDR2 (0.48) | EGFRACHEBCHEMAOAMAOB | |
| SCHEMBL6016813 | 0.71 | EGFR (0.46) | EGFRMCHR1ACHEBCHEMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |