Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 6/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5961338 | 0.88 | TBXA2R (0.40) | HDAC1HDAC6MEN1KMT2AACKR3 | |
| SCHEMBL5961320 | 0.86 | EPHX1 (0.41) | MEN1KMT2ADRD4NPC1RAB9A | |
| SCHEMBL6016947 | 0.86 | KMT2A (0.41) | MEN1KMT2AACKR3NR1H4DRD4 | |
| SCHEMBL5961345 | 0.85 | ACKR3 (0.42) | HDAC1HDAC6MEN1KMT2AACKR3 | |
| SCHEMBL6017031 | 0.85 | GAA (0.42) | HDAC1HDAC6ACKR3PTGDR2NPC1 | |
| SCHEMBL5961329 | 0.85 | RAB9A (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL5961316 | 0.84 | EPHX1 (0.42) | — | |
| SCHEMBL5961348 | 0.84 | HDAC1 (0.43) | HDAC1HDAC6MEN1KMT2AACKR3 | |
| SCHEMBL5961317 | 0.82 | EPHX2 (0.41) | MEN1KMT2AACKR3NPC1RAB9A | |
| SCHEMBL6016968 | 0.82 | ACKR3 (0.40) | MEN1KMT2AACKR3LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633726-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | Actimis Pharmaceuticals, Inc., (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004096777-A1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-11-11 | — | — | WO | disclosed |
| EP-1471057-A1 | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 | Bayer HealthCare AG (DE) | 2004-10-27 | — | — | EP | disclosed |